A ‘Trp’ to the land of Kyns

A ‘Trp’ to the land of Kyns

Breakdown of the amino acid tryptophan through the kynurenine pathway impacts a plethora of immunological processes, ranging from the starvation of invading bacteria to the induction of immunotolerance and the modulation of neurological diseases.

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Childhood vaccine controversies: the myths, the facts and the uncertainties

Childhood vaccine controversies: the myths, the facts and the uncertainties

by Dr Adli Ali Vaccine controversies and anti-vaccine movements are not something new. They began some 90 years ago in the early 20th century, even before…

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Viruses as a cure for cancer?

Viruses as a cure for cancer?

by Suet Lin Chia At a Glance: Cancer has been haunting the human population for centuries. Despite the availability of various current treatments, the number of…

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Vaccines: an immunological revolution

Vaccines: an immunological revolution

by Juliana Ariffin Did you know that if you went back in time, most of you would be immune to some of the most devastating…

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The dengue vaccine dilemma: route to prevention - are we there yet?

The dengue vaccine dilemma: route to prevention – are we there yet?

Although the Phase III clinical studies showed that Dengvaxia® was efficacious with satisfactory safety profile, we still have to continue monitoring the vaccine for long-term adverse effect by developing suitable models and active collaborations to decipher the immunological mechanisms that might be triggered by the vaccine. We also require a thorough cost-benefit analysis to determine the best option for dengue vaccination program in Malaysia. Besides, we should not neglect other approaches such as vector control and dengue hotspot identification that can benefit other mosquito-borne diseases (e.g. malaria).

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